当前位置: 网站首页 > 产品中心 > 产品详情

AF647标记的一氧化氮合成酶-2(诱导型)抗体 Rabbit Anti-iNOS/AF647 Co

货号:bs-0162R-AF647

销售价格: ¥询价(市场价:¥询价) 收藏

品牌: 北京博奥森抗体

赠送积分: 询价积分

购买数量: - +

商品货号 规格 基本价格
bs-0162R-AF647 100ul 询价
产品编号bs-0162R-AF647
英文名称Anti-iNOS/AF647
中文名称AF647标记的一氧化氮合成酶-2(诱导型)抗体
别    名i NOS; Nitric Oxide Synthase, Inducible; HEP NOS; Hepatocyte NOS; HEPNOS; Inducible nitric oxide synthase; Inducible NO synthase; Inducible NOS; INOS; Inosl; MAC NOS; Macrophage NOS; Nitric oxide synthase 2 inducible macrophage; Nitric oxide synthase 2A (inducible hepatocytes); Nitric oxide synthase inducible; NOS 2; NOS 2A; NOS; Nos II; NOS type II; Nos2; NOS2A; NOS2_HUMAN.  
规格价格100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域细胞生物  免疫学  神经生物学  信号转导  转录调节因子  激酶和磷酸酶  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, 
产品应用Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量130kDa
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human NOS-2
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains. Nitric oxide synthase is expressed in liver, macrophages, hepatocytes, synoviocytes, stimulated glial cells and smooth muscle cells. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. After cytokine induction, iNOS exhibits a delayed activity response which is then followed by a significant increase in NO production over a long period of time. Human iNOS is regulated by calcium/calmodulin (in contrast with mouse NOS2).

Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.

Subunit:
Homodimer. Binds SLC9A3R1.

Tissue Specificity:
Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.

Similarity:
Belongs to the NOS family.
Contains 1 FAD-binding FR-type domain.
Contains 1 flavodoxin-like domain.

Database links:

Entrez Gene: 4843 Human

Entrez Gene: 18126 Mouse

Entrez Gene: 24599 Rat

Omim: 163730 Human

SwissProt: P35228 Human

SwissProt: P29477 Mouse

SwissProt: Q06518 Rat

Unigene: 709191 Human

Unigene: 2893 Mouse

Unigene: 10400 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成与降解(Synthesis and Degradation)
  催化生物体内一氧化氮(NO)生成的酶。分神经型一氧化氮合成的酶(nNOS or NOS-1)、诱导型一氧化氮合成的酶(iNOS or NOS-2)、内皮型一氧化氮合成的酶(eNOS or NOS-3)。

 

客服中心

客户服务热线

请直接QQ联系!


展开客服